Chlorphenesin

Chlorphenesin(104-29-0), sunan sinadarai shine 3-(4-chlorophenoxy)propane-1,2-diol, galibi ana haɗa shi ta hanyar amsawar p-chlorophenol tare da propylene oxide ko epichlorohydrin. Maganin maganin kashe ƙwayoyin cuta ne mai faɗi da kuma maganin kashe ƙwayoyin cuta, wanda ke da tasirin maganin kashe ƙwayoyin cuta na Gram-positive, ƙwayoyin cuta na Gram-negative, yis da molds. An amince da amfani da shi a kayan kwalliya ta ƙasashe da yankuna da yawa kamar Turai, Amurka, Japan, da China. Iyakar amfani da yawancin dokoki da ƙa'idodi na ƙasa suka amince da ita shine 0.3%.
ChlorphenesinBa a fara amfani da shi azaman abin kiyayewa ba, amma a matsayin maganin hana garkuwar jiki mai alaƙa da antigen wanda ke hana sakin histamine da IgE ke haifarwa a masana'antar magunguna. A taƙaice dai, yana hana rashin lafiyan jiki. Tun daga shekarar 1967, masana'antar magunguna ta yi nazarin amfani da chlorphenesin da penicillin don hana rashin lafiyan da penicillin ke haifarwa. Sai a shekarar 1997 ne Faransawa suka gano chlorphenesin saboda tasirinsa na maganin kashe ƙwayoyin cuta da kuma bacteriostatic kuma suka yi amfani da shi don mallakar haƙƙin mallaka masu alaƙa.
1. Shin chlorphenesin yana rage tsoka?
Rahoton kimantawa ya nuna a sarari: sinadarin kwalliyar chlorphenesin ba shi da wani tasiri wajen rage tsoka. Kuma an ambaci shi sau da yawa a cikin rahoton: Duk da cewa takaitaccen sinadari na magani na Ingilishi chlorphenesin da sinadari na kwalliya chlorphenesin duka Chlorphenesin ne, bai kamata a ruɗe su biyun ba.
2. Shin chlorphenesin yana fusata fata?
Ko ga mutane ko dabbobi, chlorphenesin ba shi da ƙaiƙayi a fata a yawan da aka saba amfani da shi, kuma ba shi da na'urar tantance fata ko kuma na'urar tantance haske. Akwai labarai huɗu ko biyar kawai game da rahotannin cewa chlorphenesin yana haifar da kumburin fata. Kuma akwai wasu lokuta kaɗan inda chlorphenesin da aka yi amfani da shi ya kai kashi 0.5% zuwa 1%, wanda ya zarce yawan da aka yi amfani da shi a kayan kwalliya. A wasu lokuta da dama, an ambaci cewa chlorphenesin yana cikin dabarar, kuma babu wata shaida kai tsaye da ke nuna cewa chlorphenesin yana haifar da dermatitis. Idan aka yi la'akari da babban tushen amfani da chlorphenesin a kayan kwalliya, wannan yuwuwar ba ta da yawa.
3. Shin chlorphenesin zai shiga jini?
Gwaje-gwajen dabbobi sun nuna cewa wasu daga cikin chlorphenesin za su shiga jini bayan sun taɓa fata. Yawancin chlorphenesin da aka sha za a haɗa su a cikin fitsari, kuma za a fitar da su duka daga jiki cikin awanni 96. Amma duk wannan tsari ba zai haifar da wata illa mai guba ba.
4. Shin Chlorphenescine zai rage garkuwar jiki?
Ba zai yi ba. Chlorphenesin magani ne mai rage garkuwar jiki wanda ke da alaƙa da antigen. Da farko dai, chlorphenesin yana taka muhimmiyar rawa ne kawai idan aka haɗa shi da antigen da aka ƙayyade, kuma baya rage garkuwar jiki, kuma baya ƙara yawan kamuwa da cututtuka. Na biyu, bayan an daina amfani da shi, tasirin hana garkuwar jiki na antigen da aka ƙayyade zai ɓace, kuma ba zai sami wani tasiri mai ɗorewa ba.
5. Menene ƙarshe na binciken tsaro?
Dangane da aikace-aikacen da ake da su da kuma yawan amfani da su a Amurka (wanke-off 0.32%, nau'in mazaunin 0.30%), FDA ta yi imanin cewachlorphenesinyana da aminci a matsayin abin kiyayewa na kwalliya.