Dihydrocoumarin yana da guba

Dihydrocoumarin, kamshi, ana amfani da shi a cikin abinci, kuma ana amfani dashi azaman madadin coumarin, ana amfani dashi azaman dandano na kwaskwarima; Mix kirim, kwakwa, ɗanɗanon kirfa; Hakanan ana amfani dashi azaman dandano na taba.

Dihydrocoumarin yana da guba

Dihydrocoumarin ba mai guba bane. Dihydrocoumarin samfuri ne na halitta wanda aka samo a cikin karkanda na vanilla rawaya. Ana shirya shi ta hanyar hydrogenation na coumarin a gaban mai kara kuzari na nickel a 160-200 ℃ da kuma ƙarƙashin matsin lamba. Hakanan za'a iya amfani dashi azaman albarkatun ƙasa, hydrolyzed a cikin maganin ruwa na alkaline don samar da o-hydroxyphenylpropionic acid, bushewa, rufaffiyar madauki samu.

Yanayin ajiya

Rufewa da duhu, an adana shi a wuri mai sanyi da bushe, sararin samaniya a cikin ganga yana da ƙananan kamar yadda zai yiwu a ƙarƙashin izinin aminci, kuma yana cike da kariya ta nitrogen. Ajiye a cikin ɗakin ajiya mai sanyi, mai iska. Nisantar wuta, ruwa. Ya kamata a adana shi daban daga oxidizer, kar a haɗa ajiya. An sanye shi da daidaitattun nau'ikan da adadin kayan wuta.

Nazarin in vitro

In vitro enzymatic assay, dihydrocoumarin ya haifar da hana maida hankali-dogara na SIRT1 (IC50 na 208μM). Rage raguwa a cikin SIRT1 deacetylase ayyukan an lura ko da a micromolar allurai (85 ± 5.8 da 73 ± 13.7% ayyuka a 1.6μM da 8μM, bi da bi). Microtubule SIRT2 deacetylase kuma an hana shi ta hanyar dogaro da kashi iri ɗaya (IC50 na 295μM).

Bayan sa'o'i 24 na fallasa, dihydrocoumarin (1-5mM) ya karu cytotoxicity a cikin layin salula na TK6 ta hanyar dogaro da kashi. Dihydrocoumarin (1-5mM) ya karu apoptosis a cikin layin salula na TK6 a cikin hanyar da ta dogara da kashi a lokacin sa'o'i 6. Matsakaicin 5mM na dihydrocoumarin ya karu apoptosis a lokacin sa'o'i 6 a cikin layin salula na TK6. Bayan lokacin bayyanar sa'o'i 24, dihydrocoumarin (1-5mM) ya karu p53 lysine 373 da 382 acetylation a cikin hanyar da ta dogara da kashi a cikin layin salula na TK6.