An taɓa saninsa da "zinariya mai farar fata", kuma sunanta ya ta'allaka ne da tasirin farinta mara misaltuwa a gefe ɗaya, da kuma wahalar da ƙarancin fitar da ita a ɗayan gefen. Shukar Glycyrrhiza glabra ita ce tushen Glabridin, amma Glabridin ya ƙunshi kashi 0.1%-0.3% kawai na jimlar abubuwan da ke cikinta, wato, kilogiram 1000 na Glycyrrhiza glabra zai iya samun gram 100 kawai.Glabridin, 1g na Glabridin yayi daidai da 1g na zinariya ta zahiri.
Hikarigandine wakili ne na yau da kullun na sinadaran ganye, kuma Japan ce ta gano tasirin farin sa.
Glycyrrhiza glabra shuka ce daga cikin nau'in Glycyrrhiza. Kasar Sin ita ce kasar da ke da albarkatun ganyayyaki mafiya arziki a duniya, kuma akwai nau'ikan ganye sama da 500 da ake amfani da su a aikin likitanci, daga cikinsu akwai licorice da aka fi amfani da shi. A cewar kididdiga, yawan amfani da licorice ya wuce kashi 79%.
Saboda dogon tarihin amfani da shi, tare da kyakkyawan suna, iyakokin bincike kan darajar licorice ba wai kawai sun keta iyakokin ƙasa ba, har ma an faɗaɗa aikace-aikacen. A cewar bincike, masu amfani da kayayyaki a Asiya, musamman a Japan, suna da matuƙar girmamawa ga kayan kwalliya waɗanda ke ɗauke da sinadaran aiki na ganye. An rubuta sinadaran kayan kwalliya na ganye 114 a cikin "Kayan Kayan Kwalliya na Japan na Janar", kuma akwai nau'ikan kayan kwalliya 200 da ke ɗauke da sinadaran ganye a Japan.
An san yana da tasirin farin jini sosai, amma menene wahalhalun da ake fuskanta a aikace?
Bangaren hydrophobic na ruwan licorice yana dauke da nau'ikan flavonoids iri-iri. A matsayin babban bangaren sinadarin hydrophobic, halo-glycyrrhizidine yana da tasirin hana samar da melanin kuma yana da tasirin hana kumburi da hana oxidation.
Wasu bayanai na gwaji sun nuna cewa tasirin farin haske na Glabridin ya fi na bitamin C na yau da kullun sau 232, ya fi na hydroquinone sau 16, kuma ya fi na arbutin sau 1,164. Dangane da yadda ake samun ƙarfin aikin farin haske, haske Glabridin ya ba da hanyoyi uku daban-daban.
1. Hana aikin tyrosinase
Babban tsarin farar fata naGlabridinshine hana haɗa melanin ta hanyar hana ayyukan tyrosinase cikin gasa, cire wani ɓangare na tyrosinase daga zoben catalytic na haɗa melanin da kuma hana ɗaure substrate da tyrosinase.
2. Tasirin hana tsufa
Yana iya hana aikin tyrosinase da musayar pigment na dopa da kuma aikin dihydroxyindole carboxylic acid oxidase.
An nuna cewa a yawan sinadarin photoglycyrrhizidine da ke cikin 0.1mg/ml, yana iya aiki akan tsarin hada sinadarai na cytochrome P450/NADOH kuma yana korar kashi 67% na free radicals, wadanda ke da karfin aikin antioxidant.
3. Hana abubuwan da ke haifar da kumburi da kuma yaƙi da hasken UV
A halin yanzu, ba a sami rahotannin bincike kaɗan game da amfani da photoglycyrrhizidine a cikin nazarin ɗaukar hoton fata da UV ke haifarwa ba. A cikin 2021, a cikin wani labarin da ke cikin babban mujallar Journal of Microbiology and Biotechnology, an yi nazarin liposomes na photoglycyrrhizidine don iyawarsu na rage erythema da cututtukan fata da hasken UV ke haifarwa ta hanyar hana abubuwan kumburi. Ana iya amfani da liposomes na photoglycyrrhizidine don inganta samuwar halittu tare da ƙarancin guba tare da ingantaccen hana melanin, rage bayyanar cytokines masu kumburi, interleukin 6 da interleukin 10 yadda ya kamata. Saboda haka, ana iya amfani da shi azaman maganin warkewa na fata don magance lalacewar fata da UV ke haifarwa ta hanyar hana kumburi, wanda zai iya samar da wasu ra'ayoyi don binciken samfuran kariya daga hasken rana.
A taƙaice, an san tasirin farin haske na photoglycyrrhizidine, amma yanayinsa kusan ba ya narkewa a cikin ruwa, don haka yana da matuƙar buƙata ga tsarin samarwa da ƙera shi wajen amfani da ƙarin kayan kula da fata, kuma a halin yanzu mafita ce mai kyau ta hanyar fasahar liposome encapsulation. Bugu da ƙari, hotoGlabridinLiposomes na iya hana ɗaukar hotuna ta hanyar UV, amma wannan aikin yana buƙatar ƙarin gwaje-gwaje na asibiti don a tabbatar da su kuma a aiwatar da aikace-aikacen bincike.
Kayayyakin kula da fata da ke ɗauke da photoGlabridin a cikin nau'in haɗa sinadarai.
Duk da cewa babu shakka cewa photoGlabridine yana da kyakkyawan tasirin farar fata, farashin kayan sa kuma yana da tsauri saboda wahalhalun da ake fuskanta wajen cirewa da kuma abinda ke ciki. A fannin binciken kwalliya da kuma tsarawa, aikin sarrafa farashi yana da alaƙa kai tsaye da abubuwan da ke cikin fasaha da kuma tsarin kimiyya. Saboda haka, hanya ce mai kyau ta sarrafa farashin hadawa da kuma samun inganci mai aminci da inganci ta hanyar zabar sinadaran da ke aiki da kuma hada su da photoglycyrrhizidine. Baya ga matakin bincike da tsarawa, ana buƙatar ƙarin bincike game da binciken liposomes na photoglycyrrhizidine da sabbin dabarun cirewa.
Lokacin Saƙo: Agusta-30-2022